Tartrate-resistant acid phosphatase as a marker of bone resorption

Tartrate-resistant acid phosphatase as a marker of bone resorption.

Tartrate-resistant serum acid phosphatase was measured in 123 subjects, 80 of which were normal and the rest pathologic, in order to define the profile and value of this parameter as a biological marker of osteoclastic activity. Normal subjects were divided into age groups based on the period where skeletal growth ends (under 20 years), at the age of menopause in women (50 years, between 20 and...

Evaluation of tartrate-resistant acid phosphatase (TRACP) 5b as bone resorption marker in irradiated bone metastases.

BACKGROUND The aim of our study was to evaluate if the determination of the active isoform 5b of tartrate-resistant acid phosphatase (TRACP 5b) provides the possibility to monitor the effect of local radiotherapy in bone metastases and if TRACP 5b will predict further osseous progression. MATERIALS AND METHODS In 48 breast cancer patients with bone metastases, patients' characteristics, diagn...

Serum tartrate-resistant acid phosphatase 5b is a specific and sensitive marker of bone resorption.

ϭ the number of measurements for each calibration point x ៮ ϭ the mean values of all calibrator concentrations The resulting detection limits for normal-and low-range applications are given in Table 1. The assays were linear up to 65 mg/L for Apo A-II and 8 mg/L for Apo C-III and ApoE. For ApoA-I and ApoB, a high-dose hook effect attributable to antigen excess was observed starting at 275 mg/L ...

Polyphosphate-Mediated Inhibition of Tartrate-Resistant Acid Phosphatase and Suppression of Bone Resorption of Osteoclasts

Inorganic polyphosphate (poly(P)) has recently been found to play an important role in bone formation. In this study, we found that tartrate-resistant acid phosphatase (TRAP), which is abundantly expressed in osteoclasts, has polyphosphatase activity that degrades poly(P) and yields Pi as well as shorter poly(P) chains. Since the TRAP protein that coprecipitated with anti-TRAP monoclonal antibo...

Expression of tartrate-resistant acid phosphatase.